P63 Is an Essential Proapoptotic Protein during Neural Development
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چکیده
منابع مشابه
P63 Is an Essential Proapoptotic Protein during Neural Development
The p53 family member p63 is required for nonneural development, but has no known role in the nervous system. Here, we define an essential proapoptotic role for p63 during naturally occurring neuronal death. Sympathetic neurons express full-length TAp63 during the developmental death period, and TAp63 levels increase following NGF withdrawal. Overexpression of TAp63 causes neuronal apoptosis in...
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p63 delegates during skin development A molecular sibling of the cancer-fighting protein p53 orchestrates development of the epidermis by stimulating expression of a chromatin-reorganizing protein, Fessing et al. reveal. Although it doesn’t receive the same attention as its more famous sibling, p63 performs an equally important job. Mice lacking the protein die shortly after birth from dehydrat...
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Background and Objective: Histological grading has prognostic and therapeutic implications in meningioma. However, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. P63 gene is a novel P53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. In this stu...
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p63 is a master regulator of stratified epithelial development that is both necessary and sufficient for specifying this multifaceted program. We show here that Perp, a tetraspan membrane protein originally identified as an apoptosis-associated target of the p53 tumor suppressor, is the first direct target of p63 clearly involved in mediating this developmental program in vivo. During embryogen...
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ژورنال
عنوان ژورنال: Neuron
سال: 2005
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2005.10.027